c-kit+ Cardiac Stem Cells
نویسندگان
چکیده
One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit cardiac stem cells in the heart and their contribution toward cardiac homeostasis. A recent study reports that a subpopulation of c-kit cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC-derived c-kit cells to cardiac myocyte development is regulated by bone morphogenetic protein (BMP). However, ex vivo manipulation of CNC cells reveals efficient transformation to early cardiac progenitors.
منابع مشابه
Resident c-kit+ cells in the heart are not cardiac stem cells
Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By t...
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